645 Ventures

645 Ventures is a New York and San Francisco-based early-stage venture capital firm founded in 2013 by Nnamdi Okike, a Harvard Business School graduate and former Insight Partners executive, and Aaron Holiday, a former Goldman Sachs program trading engineer and founding Managing Entrepreneurial Officer at Cornell Tech. The firm takes a data-driven approach to venture investing, using proprietary software called Voyager to systematically source and score investment opportunities beyond personal networks, and applies a Venture Investment Triangle framework to evaluate companies across market size, competitive dynamics, and founder background. 645 Ventures invests primarily at seed and Series A stages, with initial checks of $1 million to $5 million at seed and $5 million to $10 million at Series A, and manages over $500 million in committed capital including a Select Fund that follows its highest-performing companies into growth rounds with investments of $10 to $15 million. The firm focuses on enterprise SaaS, infrastructure software, consumer technology, fintech, AI, and Web3. Founded in New York with a deep belief in the city's technology ecosystem, the firm expanded to San Francisco in 2021. It has backed 79 companies with two unicorns among them. Beyond its original investments in Brex, Kustomer, Nylas, and Roofstock, the firm's portfolio includes Iterable, Goldbelly, Squire, Overtime, Eden Health, Panther Labs, FiscalNote, Nanit, BespokePost, Shop Circle, Shift5, and True Anomaly, spanning B2B software, consumer brands, fintech, and defense technology.